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Mutant Fibulin-3 Causes Proteoglycan Accumulation and Impaired Diffusion Across Bruch's Membrane
PURPOSE: The mutation R345W in EFEMP1 (fibulin-3) causes macular degeneration. This study sought to determine whether proteoglycan content and diffusion across Bruch's membrane are altered in Efemp1(ki/ki) mice carrying this mutation or in Efemp1(−/−) mice. METHODS: Proteoglycans in mouse Bruch...
Autores principales: | Zayas-Santiago, Astrid, Cross, Samuel D., Stanton, James B., Marmorstein, Alan D., Marmorstein, Lihua Y. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477800/ https://www.ncbi.nlm.nih.gov/pubmed/28622396 http://dx.doi.org/10.1167/iovs.17-21720 |
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