High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance

Antibiotic-resistant infections kill approximately 23,000 people and cost $20,000,000,000 each year in the United States alone despite the widespread use of small-molecule antimicrobial combination therapy. Antibiotic combinations typically have an additive effect: the efficacy of the combination ma...

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Detalles Bibliográficos
Autores principales: Wambaugh, Morgan A., Shakya, Viplendra P. S., Lewis, Adam J., Mulvey, Matthew A., Brown, Jessica C. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478098/
https://www.ncbi.nlm.nih.gov/pubmed/28632788
http://dx.doi.org/10.1371/journal.pbio.2001644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478098/
https://www.ncbi.nlm.nih.gov/pubmed/28632788
http://dx.doi.org/10.1371/journal.pbio.2001644

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