MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression

Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a “cytokine storm” with severe and sometimes life-threatening consequences typically encountered in toxic shock syndrome (TSS). Given...

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Detalles Bibliográficos
Autores principales: Shaler, Christopher R., Choi, Joshua, Rudak, Patrick T., Memarnejadian, Arash, Szabo, Peter A., Tun-Abraham, Mauro E., Rossjohn, Jamie, Corbett, Alexandra J., McCluskey, James, McCormick, John K., Lantz, Olivier, Hernandez-Alejandro, Roberto, Haeryfar, S.M. Mansour
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478099/
https://www.ncbi.nlm.nih.gov/pubmed/28632753
http://dx.doi.org/10.1371/journal.pbio.2001930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478099/
https://www.ncbi.nlm.nih.gov/pubmed/28632753
http://dx.doi.org/10.1371/journal.pbio.2001930

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