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Computational design of ligand binding membrane receptors with high selectivity

Accurate modeling and design of protein-ligand interactions have broad applications in cell, synthetic biology and drug discovery but remain challenging without experimental protein structures. Here we developed an integrated protein homology modeling-ligand docking-protein design approach that reco...

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Detalles Bibliográficos
Autores principales: Feng, X., Ambia, J., Chen, K-Y., Young, M., Barth, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478435/
https://www.ncbi.nlm.nih.gov/pubmed/28459439
http://dx.doi.org/10.1038/nchembio.2371