Lipid II overproduction allows direct assay of transpeptidase inhibition by β-lactams

Peptidoglycan is an essential crosslinked polymer that surrounds bacteria and protects them from osmotic lysis. Beta-lactam antibiotics target the final stages of peptidoglycan biosynthesis by inhibiting the transpeptidases that crosslink glycan strands to complete cell wall assembly. Characterizati...

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Detalles Bibliográficos
Autores principales: Qiao, Yuan, Srisuknimit, Veerasak, Rubino, Frederick, Schaefer, Kaitlin, Ruiz, Natividad, Walker, Suzanne, Kahne, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478438/
https://www.ncbi.nlm.nih.gov/pubmed/28553948
http://dx.doi.org/10.1038/nchembio.2388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478438/
https://www.ncbi.nlm.nih.gov/pubmed/28553948
http://dx.doi.org/10.1038/nchembio.2388

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