Mutations in human AID differentially affect its ability to deaminate cytidine and 5-methylcytidine in ssDNA substrates in vitro

Activation-induced cytidine deaminase (AID) is known for its established role in antibody production. AID induces the diversification of antibodies by deaminating deoxycytidine (C) within immunoglobulin genes. The capacity of AID to deaminate 5-methyldeoxycytidine (5 mC) and/or 5-hydroxymethyldeoxyc...

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Detalles Bibliográficos
Autores principales: Budzko, Lucyna, Jackowiak, Paulina, Kamel, Karol, Sarzynska, Joanna, Bujnicki, Janusz M., Figlerowicz, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478644/
https://www.ncbi.nlm.nih.gov/pubmed/28634398
http://dx.doi.org/10.1038/s41598-017-03936-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478644/
https://www.ncbi.nlm.nih.gov/pubmed/28634398
http://dx.doi.org/10.1038/s41598-017-03936-x

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