Cargando…
Osteopontin is Critical for Hyperactive mTOR-Induced Tumorigenesis in Oral Squamous Cell Carcinoma
Mechanistic target of rapamycin (mTOR) plays a critical role in the development of oral squamous cell carcinoma (OSCC), but the underlying mechanisms remain poorly understood. Here we have demonstrated that the expression of osteopontin (OPN) was dramatically up-regulated in OSCC tissues and cell li...
Autores principales: | Gan, Ning, Zou, Sihai, Hang, Wenming, Yang, Deqin, Zhang, Xuemei, Yin, Yibing |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479241/ https://www.ncbi.nlm.nih.gov/pubmed/28638450 http://dx.doi.org/10.7150/jca.18031 |
Ejemplares similares
-
Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy
por: Yuan, RuiRong, et al.
Publicado: (2009) -
RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma
por: Lu, Zhaoming, et al.
Publicado: (2020) -
Normalizing a hyperactive mTOR initiates muscle growth during obesity
por: Williamson, David L., et al.
Publicado: (2011) -
Depdc5 knockdown causes mTOR‐dependent motor hyperactivity in zebrafish
por: de Calbiac, Hortense, et al.
Publicado: (2018) -
ubtor Mutation Causes Motor Hyperactivity by Activating mTOR Signaling in Zebrafish
por: Wang, Tiantian, et al.
Publicado: (2021)