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Selective propagation of mouse-passaged scrapie prions with long incubation period from a mixed prion population using GT1-7 cells

In our previous study, we demonstrated the propagation of mouse-passaged scrapie isolates with long incubation periods (L-type) derived from natural Japanese sheep scrapie cases in murine hypothalamic GT1-7 cells, along with disease-associated prion protein (PrP(Sc)) accumulation. We here analyzed t...

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Detalles Bibliográficos
Autores principales: Miyazawa, Kohtaro, Masujin, Kentaro, Okada, Hiroyuki, Ushiki-Kaku, Yuko, Matsuura, Yuichi, Yokoyama, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479544/
https://www.ncbi.nlm.nih.gov/pubmed/28636656
http://dx.doi.org/10.1371/journal.pone.0179317