Novel siRNA formulation to effectively knockdown mutant p53 in osteosarcoma

OBJECTIVES: The tumor suppressor p53 plays a crucial role in the development of osteosarcoma. The primary objective of this study is to develop and optimize lipid based nanoparticle formulations that can carry siRNA and effectively silence mutant p53 in 318–1, a murine osteosarcoma cell line. METHOD...

Descripción completa

Detalles Bibliográficos
Autores principales: Kundu, Anup K., Iyer, Swathi V., Chandra, Sruti, Adhikari, Amit S., Iwakuma, Tomoo, Mandal, Tarun K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479560/
https://www.ncbi.nlm.nih.gov/pubmed/28636657
http://dx.doi.org/10.1371/journal.pone.0179168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479560/
https://www.ncbi.nlm.nih.gov/pubmed/28636657
http://dx.doi.org/10.1371/journal.pone.0179168

Ejemplares similares