Cargando…
Novel siRNA formulation to effectively knockdown mutant p53 in osteosarcoma
OBJECTIVES: The tumor suppressor p53 plays a crucial role in the development of osteosarcoma. The primary objective of this study is to develop and optimize lipid based nanoparticle formulations that can carry siRNA and effectively silence mutant p53 in 318–1, a murine osteosarcoma cell line. METHOD...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479560/ https://www.ncbi.nlm.nih.gov/pubmed/28636657 http://dx.doi.org/10.1371/journal.pone.0179168 |