The cannabinoid ligand LH-21 reduces anxiety and improves glucose handling in diet-induced obese pre-diabetic mice

LH-21 is a triazol derivative that has been described as a low-permeant neutral CB1 antagonist, though its pharmacology is still unclear. It has been associated with anti-obesity actions in obese rats. However, its role in preventing type 2 diabetes (T2D) onset have not been studied yet. Given CB1 r...

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Detalles Bibliográficos
Autores principales: Romero-Zerbo, Silvana Y., Ruz-Maldonado, Inmaculada, Espinosa-Jiménez, Vanesa, Rafacho, Alex, Gómez-Conde, Ana I., Sánchez-Salido, Lourdes, Cobo-Vuilleumier, Nadia, Gauthier, Benoit R., Tinahones, Francisco J., Persaud, Shanta J., Bermúdez-Silva, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479807/
https://www.ncbi.nlm.nih.gov/pubmed/28638091
http://dx.doi.org/10.1038/s41598-017-03292-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479807/
https://www.ncbi.nlm.nih.gov/pubmed/28638091
http://dx.doi.org/10.1038/s41598-017-03292-w

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