Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice

Maternal folate deficiency is linked to restricted fetal growth, however the underlying mechanisms remain to be established. Here we tested the hypothesis that mTOR functions as a folate sensor in vivo in mice and that maternal folate deficiency inhibits placental mTOR signaling and amino acid trans...

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Detalles Bibliográficos
Autores principales: Rosario, Fredrick J., Nathanielsz, Peter W., Powell, Theresa L., Jansson, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479823/
https://www.ncbi.nlm.nih.gov/pubmed/28638048
http://dx.doi.org/10.1038/s41598-017-03888-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479823/
https://www.ncbi.nlm.nih.gov/pubmed/28638048
http://dx.doi.org/10.1038/s41598-017-03888-2

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