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Conformational plasticity and evolutionary analysis of the myotilin tandem Ig domains

Myotilin is a component of the sarcomere where it plays an important role in organisation and maintenance of Z-disk integrity. This involves direct binding to F-actin and filamin C, a function mediated by its Ig domain pair. While the structures of these two individual domains are known, information...

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Detalles Bibliográficos
Autores principales: Puž, Vid, Pavšič, Miha, Lenarčič, Brigita, Djinović-Carugo, Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479843/
https://www.ncbi.nlm.nih.gov/pubmed/28638118
http://dx.doi.org/10.1038/s41598-017-03323-6