The NF1 somatic mutational landscape in sporadic human cancers

BACKGROUND: Neurofibromatosis type 1 (NF1: Online Mendelian Inheritance in Man (OMIM) #162200) is an autosomal dominantly inherited tumour predisposition syndrome. Heritable constitutional mutations in the NF1 gene result in dysregulation of the RAS/MAPK pathway and are causative of NF1. The major k...

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Detalles Bibliográficos
Autores principales: Philpott, Charlotte, Tovell, Hannah, Frayling, Ian M., Cooper, David N., Upadhyaya, Meena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480124/
https://www.ncbi.nlm.nih.gov/pubmed/28637487
http://dx.doi.org/10.1186/s40246-017-0109-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480124/
https://www.ncbi.nlm.nih.gov/pubmed/28637487
http://dx.doi.org/10.1186/s40246-017-0109-3

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