Continuous long-term cytotoxicity monitoring in 3D spheroids of beetle luciferase-expressing hepatocytes by nondestructive bioluminescence measurement

BACKGROUND: Three-dimensional (3D) spheroids are frequently used in toxicological study because their morphology and function closely resemble those of tissue. As these properties are maintained over a long term, repeated treatment of the spheroids with a test object is possible. Generally, in the r...

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Detalles Bibliográficos
Autores principales: Yasunaga, Mayu, Fujita, Yasuko, Saito, Rumiko, Oshimura, Mitsuo, Nakajima, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480146/
https://www.ncbi.nlm.nih.gov/pubmed/28637431
http://dx.doi.org/10.1186/s12896-017-0374-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480146/
https://www.ncbi.nlm.nih.gov/pubmed/28637431
http://dx.doi.org/10.1186/s12896-017-0374-1

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