Examination of multiple UGT1A and DPYD polymorphisms has limited ability to predict the toxicity and efficacy of metastatic colorectal cancer treated with irinotecan-based chemotherapy: a retrospective analysis

BACKGROUND: To evaluate a new UGT1A and DPYD polymorphism panel to better predict irinotecan-induced toxicity and the clinical response in Chinese patients with metastatic colorectal cancer (mCRC). METHODS: The genotypes of UGT1A (UGT1A1*6, UGT1A1*27, UGT1A1*28, UGT1A7*2, UGT1A7*3, UGT1A7*4 and UGT1...

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Detalles Bibliográficos
Autores principales: Liu, Dan, Li, Jian, Gao, Jing, Li, Yanyan, Yang, Rui, Shen, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480170/
https://www.ncbi.nlm.nih.gov/pubmed/28637434
http://dx.doi.org/10.1186/s12885-017-3406-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480170/
https://www.ncbi.nlm.nih.gov/pubmed/28637434
http://dx.doi.org/10.1186/s12885-017-3406-2

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