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The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells

The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays critical roles in orchestrating of immune system, especially cytokine receptors and they can modulate the polarization of T helper cells. This pathway is regulated by an array of regulator proteins, includin...

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Autores principales: Seif, Farhad, Khoshmirsafa, Majid, Aazami, Hossein, Mohsenzadegan, Monireh, Sedighi, Gholamreza, Bahar, Mohammadali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480189/
https://www.ncbi.nlm.nih.gov/pubmed/28637459
http://dx.doi.org/10.1186/s12964-017-0177-y
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author Seif, Farhad
Khoshmirsafa, Majid
Aazami, Hossein
Mohsenzadegan, Monireh
Sedighi, Gholamreza
Bahar, Mohammadali
author_facet Seif, Farhad
Khoshmirsafa, Majid
Aazami, Hossein
Mohsenzadegan, Monireh
Sedighi, Gholamreza
Bahar, Mohammadali
author_sort Seif, Farhad
collection PubMed
description The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays critical roles in orchestrating of immune system, especially cytokine receptors and they can modulate the polarization of T helper cells. This pathway is regulated by an array of regulator proteins, including Suppressors of Cytokine Signaling (SOCS), Protein Inhibitors of Activated STATs (PIAS) and Protein Tyrosine Phosphatases (PTPs) determining the initiation, duration and termination of the signaling cascades. Dysregulation of the JAK-STAT pathway in T helper cells may result in various immune disorders. In this review, we represent how the JAK-STAT pathway is generally regulated and then in Th cell subsets in more detail. Finally, we introduce novel targeted strategies as promising therapeutic approaches in the treatment of immune disorders. Studies are ongoing for identifying the other regulators of the JAK-STAT pathway and designing innovative therapeutic strategies. Therefore, further investigation is needed.
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spelling pubmed-54801892017-06-23 The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells Seif, Farhad Khoshmirsafa, Majid Aazami, Hossein Mohsenzadegan, Monireh Sedighi, Gholamreza Bahar, Mohammadali Cell Commun Signal Review The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays critical roles in orchestrating of immune system, especially cytokine receptors and they can modulate the polarization of T helper cells. This pathway is regulated by an array of regulator proteins, including Suppressors of Cytokine Signaling (SOCS), Protein Inhibitors of Activated STATs (PIAS) and Protein Tyrosine Phosphatases (PTPs) determining the initiation, duration and termination of the signaling cascades. Dysregulation of the JAK-STAT pathway in T helper cells may result in various immune disorders. In this review, we represent how the JAK-STAT pathway is generally regulated and then in Th cell subsets in more detail. Finally, we introduce novel targeted strategies as promising therapeutic approaches in the treatment of immune disorders. Studies are ongoing for identifying the other regulators of the JAK-STAT pathway and designing innovative therapeutic strategies. Therefore, further investigation is needed. BioMed Central 2017-06-21 /pmc/articles/PMC5480189/ /pubmed/28637459 http://dx.doi.org/10.1186/s12964-017-0177-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Seif, Farhad
Khoshmirsafa, Majid
Aazami, Hossein
Mohsenzadegan, Monireh
Sedighi, Gholamreza
Bahar, Mohammadali
The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells
title The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells
title_full The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells
title_fullStr The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells
title_full_unstemmed The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells
title_short The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells
title_sort role of jak-stat signaling pathway and its regulators in the fate of t helper cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480189/
https://www.ncbi.nlm.nih.gov/pubmed/28637459
http://dx.doi.org/10.1186/s12964-017-0177-y
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