Characterization of non-heme iron aliphatic halogenase WelO5* from Hapalosiphon welwitschii IC-52-3: Identification of a minimal protein sequence motif that confers enzymatic chlorination specificity in the biosynthesis of welwitindolelinones

The in vitro biochemical characterization revealed that iron/2-oxoglutarate (Fe/2OG)-dependent aliphatic halogenase WelO5* in Hapalosiphon welwitschii IC-52-3 has an enhanced substrate specificity towards 12-epi-hapalindole C (1) in comparison to WelO5 in H. welwitschii UTEX B1830. This allowed us t...

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Detalles Bibliográficos
Autores principales: Zhu, Qin, Liu, Xinyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480362/
https://www.ncbi.nlm.nih.gov/pubmed/28684995
http://dx.doi.org/10.3762/bjoc.13.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480362/
https://www.ncbi.nlm.nih.gov/pubmed/28684995
http://dx.doi.org/10.3762/bjoc.13.115

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