EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice

Metabolic pathways contributing to adiposity and aging are activated by the mammalian target of rapamycin complex 1 (mTORC1) and p70 ribosomal protein S6 kinase 1 (S6K1) axis(1–3). However, known mTORC1-S6K1 targets do not account for observed loss-of-function phenotypes, suggesting additional downs...

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Detalles Bibliográficos
Autores principales: Arif, Abul, Terenzi, Fulvia, Potdar, Alka A., Jia, Jie, Sacks, Jessica, China, Arnab, Halawani, Dalia, Vasu, Kommireddy, Li, Xiaoxia, Brown, J. Mark, Chen, Jie, Kozma, Sara C., Thomas, George, Fox, Paul L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480610/
https://www.ncbi.nlm.nih.gov/pubmed/28178239
http://dx.doi.org/10.1038/nature21380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480610/
https://www.ncbi.nlm.nih.gov/pubmed/28178239
http://dx.doi.org/10.1038/nature21380

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