Bilateral blockade of MEK- and PI3K-mediated pathways downstream of mutant KRAS as a treatment approach for peritoneal mucinous malignancies

Mucinous colorectal adenocarcinomas (MCAs) are clinically and morphologically distinct from nonmucinous colorectal cancers (CRCs), show a distinct spectrum of genetic alterations (higher KRAS mutations, lower p53, high MUC2), exhibit more aggressive behavior (more prone to peritoneal dissemination a...

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Detalles Bibliográficos
Autores principales: Kuracha, Murali R., Thomas, Peter, Loggie, Brian W., Govindarajan, Venkatesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480880/
https://www.ncbi.nlm.nih.gov/pubmed/28640835
http://dx.doi.org/10.1371/journal.pone.0179510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480880/
https://www.ncbi.nlm.nih.gov/pubmed/28640835
http://dx.doi.org/10.1371/journal.pone.0179510

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