Distinct Roles of RNA Helicases MVH and TDRD9 in PIWI Slicing-Triggered Mammalian piRNA Biogenesis and Function

Small RNAs called PIWI-interacting RNAs (piRNAs) act as an immune system to suppress transposable elements in the animal gonads. A poorly understood adaptive pathway links cytoplasmic slicing of target RNA by the PIWI protein MILI to loading of target-derived piRNAs into nuclear MIWI2. Here we demon...

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Detalles Bibliográficos
Autores principales: Wenda, Joanna M., Homolka, David, Yang, Zhaolin, Spinelli, Pietro, Sachidanandam, Ravi, Pandey, Radha Raman, Pillai, Ramesh S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481186/
https://www.ncbi.nlm.nih.gov/pubmed/28633017
http://dx.doi.org/10.1016/j.devcel.2017.05.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481186/
https://www.ncbi.nlm.nih.gov/pubmed/28633017
http://dx.doi.org/10.1016/j.devcel.2017.05.021

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