In silico Discovery of Novel FXa Inhibitors by Pharmacophore Modeling and Molecular Docking

ABSTRACT: Coagulation Factor Xa (FXa) is the crucial enzyme at the convergent point of the intrinsic and extrinsic coagulation pathways. The inhibition of FXa is an effective approach against thrombotic diseases. In the present study, a specific strategy is reported to discover 10 novel FXa inhibito...

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Detalles Bibliográficos
Autores principales: Pu, Yinglan, Liu, Hui, Zhou, Yeheng, Peng, Jiale, Li, Yaping, Li, Penghua, Li, Yingying, Liu, Xingyong, Zhang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481271/
https://www.ncbi.nlm.nih.gov/pubmed/28577290
http://dx.doi.org/10.1007/s13659-017-0126-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481271/
https://www.ncbi.nlm.nih.gov/pubmed/28577290
http://dx.doi.org/10.1007/s13659-017-0126-x

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