Protection of Mice from Acute Graft-versus-Host Disease Requires CD28 Co-stimulation on Donor CD4(+) Foxp3(+) Regulatory T Cells

Acute graft-versus-host disease (aGvHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell plus T cell transplantation (allo-HSCT). In this study, we investigated the requirement for CD28 co-stimulation of donor CD4(+) conventional (CD4(+)CD25(−)Foxp3(−), Tconv) and...

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Detalles Bibliográficos
Autores principales: Uri, Anna, Werner, Sandra, Lühder, Fred, Hünig, Thomas, Kerkau, Thomas, Beyersdorf, Niklas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481316/
https://www.ncbi.nlm.nih.gov/pubmed/28690612
http://dx.doi.org/10.3389/fimmu.2017.00721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481316/
https://www.ncbi.nlm.nih.gov/pubmed/28690612
http://dx.doi.org/10.3389/fimmu.2017.00721

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