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Protection of Mice from Acute Graft-versus-Host Disease Requires CD28 Co-stimulation on Donor CD4(+) Foxp3(+) Regulatory T Cells

Acute graft-versus-host disease (aGvHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell plus T cell transplantation (allo-HSCT). In this study, we investigated the requirement for CD28 co-stimulation of donor CD4(+) conventional (CD4(+)CD25(−)Foxp3(−), Tconv) and...

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Detalles Bibliográficos
Autores principales:	Uri, Anna, Werner, Sandra, Lühder, Fred, Hünig, Thomas, Kerkau, Thomas, Beyersdorf, Niklas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481316/ https://www.ncbi.nlm.nih.gov/pubmed/28690612 http://dx.doi.org/10.3389/fimmu.2017.00721

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