Acute loss of the hepatic endo-lysosomal system in vivo causes compensatory changes in iron homeostasis

Liver cells communicate with the extracellular environment to take up nutrients via endocytosis. Iron uptake is essential for metabolic activities and cell homeostasis. Here, we investigated the role of the endocytic system for maintaining iron homeostasis. We specifically depleted the small GTPase...

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Detalles Bibliográficos
Autores principales: Metzendorf, Christoph, Zeigerer, Anja, Seifert, Sarah, Sparla, Richard, Najafi, Bahar, Canonne-Hergaux, François, Zerial, Marino, Muckenthaler, Martina U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481338/
https://www.ncbi.nlm.nih.gov/pubmed/28642463
http://dx.doi.org/10.1038/s41598-017-02898-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481338/
https://www.ncbi.nlm.nih.gov/pubmed/28642463
http://dx.doi.org/10.1038/s41598-017-02898-4

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