Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral Activity

Tylophorine-based compounds exert broad spectral, potent inhibition of coronaviruses. NF-κB activation is a common pro-inflammatory response of host cells to viral infection. The aims of this study were to (i) find an effective combination treatment for coronaviral infections through targeting of th...

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Detalles Bibliográficos
Autores principales: Yang, Cheng-Wei, Lee, Yue-Zhi, Hsu, Hsing-Yu, Shih, Chuan, Chao, Yu-Sheng, Chang, Hwan-You, Lee, Shiow-Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481340/
https://www.ncbi.nlm.nih.gov/pubmed/28642467
http://dx.doi.org/10.1038/s41598-017-04203-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481340/
https://www.ncbi.nlm.nih.gov/pubmed/28642467
http://dx.doi.org/10.1038/s41598-017-04203-9

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