Predicting effects on oxaliplatin clearance: in vitro, kinetic and clinical studies of calcium- and magnesium-mediated oxaliplatin degradation

This study evaluated the impact of calcium and magnesium on the in vitro degradation and in vivo clearance of oxaliplatin. Intact oxaliplatin and Pt(DACH)Cl(2) were measured in incubation solutions by HPLC-UV. A clinical study determined changes in plasma concentrations of calcium and magnesium in c...

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Detalles Bibliográficos
Autores principales: Han, Catherine H., Khwaounjoo, Prashannata, Hill, Andrew G., Miskelly, Gordon M., McKeage, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481441/
https://www.ncbi.nlm.nih.gov/pubmed/28642473
http://dx.doi.org/10.1038/s41598-017-04383-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481441/
https://www.ncbi.nlm.nih.gov/pubmed/28642473
http://dx.doi.org/10.1038/s41598-017-04383-4

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