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Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification

Terpenoid natural products comprise a wide range of molecular architectures that typically result from C–C bond formations catalysed by classical type I/II terpene cyclases. However, the molecular diversity of biologically active terpenoids is substantially increased by fully unrelated, non-canonica...

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Detalles Bibliográficos
Autores principales: Kugel, Susann, Baunach, Martin, Baer, Philipp, Ishida-Ito, Mie, Sundaram, Srividhya, Xu, Zhongli, Groll, Michael, Hertweck, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481743/
https://www.ncbi.nlm.nih.gov/pubmed/28643772
http://dx.doi.org/10.1038/ncomms15804