Integrative approach in the era of failing drug discovery and development

The productivity decline in drug discovery and development is mainly caused by two factors; higher regulatory hurdles and low-hanging fruits being all picked. In addition, the recent target-based approach is thought to be increasing the price of innovation. Although target-based approach had many su...

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Detalles Bibliográficos
Autores principales: Earm, Keehyun, Earm, Yung E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481768/
https://www.ncbi.nlm.nih.gov/pubmed/28664100
http://dx.doi.org/10.1016/j.imr.2014.09.002
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author Earm, Keehyun
Earm, Yung E.
author_facet Earm, Keehyun
Earm, Yung E.
author_sort Earm, Keehyun
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description The productivity decline in drug discovery and development is mainly caused by two factors; higher regulatory hurdles and low-hanging fruits being all picked. In addition, the recent target-based approach is thought to be increasing the price of innovation. Although target-based approach had many successes, a postreductionism method, which is systems biology, is on the rise. In this review, we discuss the foundations of two distinct approaches in finding a new drug.
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spelling pubmed-54817682017-06-29 Integrative approach in the era of failing drug discovery and development Earm, Keehyun Earm, Yung E. Integr Med Res Review Article The productivity decline in drug discovery and development is mainly caused by two factors; higher regulatory hurdles and low-hanging fruits being all picked. In addition, the recent target-based approach is thought to be increasing the price of innovation. Although target-based approach had many successes, a postreductionism method, which is systems biology, is on the rise. In this review, we discuss the foundations of two distinct approaches in finding a new drug. Elsevier 2014-12 2014-09-10 /pmc/articles/PMC5481768/ /pubmed/28664100 http://dx.doi.org/10.1016/j.imr.2014.09.002 Text en © 2014 Korea Institute of Oriental Medicine. Published by Elsevier. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Earm, Keehyun
Earm, Yung E.
Integrative approach in the era of failing drug discovery and development
title Integrative approach in the era of failing drug discovery and development
title_full Integrative approach in the era of failing drug discovery and development
title_fullStr Integrative approach in the era of failing drug discovery and development
title_full_unstemmed Integrative approach in the era of failing drug discovery and development
title_short Integrative approach in the era of failing drug discovery and development
title_sort integrative approach in the era of failing drug discovery and development
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481768/
https://www.ncbi.nlm.nih.gov/pubmed/28664100
http://dx.doi.org/10.1016/j.imr.2014.09.002
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