DOT1L safeguards cartilage homeostasis and protects against osteoarthritis

Osteoarthritis is the most prevalent and crippling joint disease, and lacks curative treatment, as the underlying molecular basis is unclear. Here, we show that DOT1L, an enzyme involved in histone methylation, is a master protector of cartilage health. Loss of DOT1L disrupts the molecular signature...

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Detalles Bibliográficos
Autores principales: Monteagudo, Silvia, Cornelis, Frederique M. F., Aznar-Lopez, Carolina, Yibmantasiri, Ploi, Guns, Laura-An, Carmeliet, Peter, Cailotto, Frédéric, Lories, Rik J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481839/
https://www.ncbi.nlm.nih.gov/pubmed/28627522
http://dx.doi.org/10.1038/ncomms15889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481839/
https://www.ncbi.nlm.nih.gov/pubmed/28627522
http://dx.doi.org/10.1038/ncomms15889

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