Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis

BACKGROUND: Perturbation of commensal intestinal microbiota has been associated with several autoimmune diseases. Mice deficient in interleukin-1 receptor antagonist (Il1rn (−/−) mice) spontaneously develop autoimmune arthritis and are susceptible to other autoimmune diseases such as psoriasis, diab...

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Detalles Bibliográficos
Autores principales: Rogier, Rebecca, Ederveen, Thomas H. A., Boekhorst, Jos, Wopereis, Harm, Scher, Jose U., Manasson, Julia, Frambach, Sanne J. C. M., Knol, Jan, Garssen, Johan, van der Kraan, Peter M., Koenders, Marije I., van den Berg, Wim B., van Hijum, Sacha A. F. T., Abdollahi-Roodsaz, Shahla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481968/
https://www.ncbi.nlm.nih.gov/pubmed/28645307
http://dx.doi.org/10.1186/s40168-017-0278-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481968/
https://www.ncbi.nlm.nih.gov/pubmed/28645307
http://dx.doi.org/10.1186/s40168-017-0278-2

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