Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles

Synaptic transmission requires a stable pool of release-ready (primed) vesicles. Here we show that two molecules involved in SNARE-complex assembly, Munc13-1 and Munc18-1, together stabilize release-ready vesicles by preventing de-priming. Replacing neuronal Munc18-1 by a non-neuronal isoform Munc18...

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Detalles Bibliográficos
Autores principales: He, Enqi, Wierda, Keimpe, van Westen, Rhode, Broeke, Jurjen H., Toonen, Ruud F., Cornelisse, L. Niels, Verhage, Matthijs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482055/
https://www.ncbi.nlm.nih.gov/pubmed/28635948
http://dx.doi.org/10.1038/ncomms15915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482055/
https://www.ncbi.nlm.nih.gov/pubmed/28635948
http://dx.doi.org/10.1038/ncomms15915

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