ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells

Type 1 regulatory T (Tr1) cells differentiate in response to signals engaging the T cell receptor (TCR), express high levels of the immunosuppressive cytokine IL-10, but not Foxp3, and can suppress inflammation and promote immune tolerance. Here we show that ITK, an important modulator of TCR signal...

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Detalles Bibliográficos
Autores principales: Huang, Weishan, Solouki, Sabrina, Koylass, Nicholas, Zheng, Song-Guo, August, Avery
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482062/
https://www.ncbi.nlm.nih.gov/pubmed/28635957
http://dx.doi.org/10.1038/ncomms15871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482062/
https://www.ncbi.nlm.nih.gov/pubmed/28635957
http://dx.doi.org/10.1038/ncomms15871

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