Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts

During bone remodelling, osteoclasts induce chemotaxis of osteoblasts and yet maintain spatial segregation. We show that osteoclasts express the repulsive guidance factor Semaphorin 4D and induce contact inhibition of locomotion (CIL) in osteoblasts through its receptor Plexin-B1. To examine causali...

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Detalles Bibliográficos
Autores principales: Deb Roy, Abhijit, Yin, Taofei, Choudhary, Shilpa, Rodionov, Vladimir, Pilbeam, Carol C., Wu, Yi I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482063/
https://www.ncbi.nlm.nih.gov/pubmed/28635959
http://dx.doi.org/10.1038/ncomms15831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482063/
https://www.ncbi.nlm.nih.gov/pubmed/28635959
http://dx.doi.org/10.1038/ncomms15831

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