Focally perfused succinate potentiates brain metabolism in head injury patients

Following traumatic brain injury, complex cerebral energy perturbations occur. Correlating with unfavourable outcome, high brain extracellular lactate/pyruvate ratio suggests hypoxic metabolism and/or mitochondrial dysfunction. We investigated whether focal administration of succinate, a tricarboxyl...

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Detalles Bibliográficos
Autores principales: Jalloh, Ibrahim, Helmy, Adel, Howe, Duncan J, Shannon, Richard J, Grice, Peter, Mason, Andrew, Gallagher, Clare N, Stovell, Matthew G, van der Heide, Susan, Murphy, Michael P, Pickard, John D, Menon, David K, Carpenter, T Adrian, Hutchinson, Peter J, Carpenter, Keri LH
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482384/
https://www.ncbi.nlm.nih.gov/pubmed/27798266
http://dx.doi.org/10.1177/0271678X16672665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482384/
https://www.ncbi.nlm.nih.gov/pubmed/27798266
http://dx.doi.org/10.1177/0271678X16672665

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