Swapping the N- and C-terminal domains of human apolipoprotein E3 and AI reveals insights into their structure/activity relationship

Apolipoprotein (apo) E3 and apoAI are exchangeable apolipoproteins that play a dominant role in regulating plasma lipoprotein metabolism. ApoE3 (299 residues) is composed of an N-terminal (NT) domain bearing a 4-helix bundle and a C-terminal (CT) domain bearing a series of amphipathic α-helices. Apo...

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Detalles Bibliográficos
Autores principales: Lek, Mark T., Cruz, Siobanth, Ibe, Nnejiuwa U., Beck, Wendy H. J., Bielicki, John K., Weers, Paul M. M., Narayanaswami, Vasanthy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482431/
https://www.ncbi.nlm.nih.gov/pubmed/28644829
http://dx.doi.org/10.1371/journal.pone.0178346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482431/
https://www.ncbi.nlm.nih.gov/pubmed/28644829
http://dx.doi.org/10.1371/journal.pone.0178346

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