Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells

The robust glycolytic metabolism of glioblastoma multiforme (GBM) has proven them susceptible to increases in oxidative metabolism induced by the pyruvate mimetic dichloroacetate (DCA). Recent reports demonstrate that the anti-diabetic drug metformin enhances the damaging oxidative stress associated...

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Detalles Bibliográficos
Autores principales: Ward, Nathan P., Poff, Angela M., Koutnik, Andrew P., D’Agostino, Dominic P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482478/
https://www.ncbi.nlm.nih.gov/pubmed/28644886
http://dx.doi.org/10.1371/journal.pone.0180061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482478/
https://www.ncbi.nlm.nih.gov/pubmed/28644886
http://dx.doi.org/10.1371/journal.pone.0180061

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