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Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11

Based on observations of markers for DNA lesions, such as phosphorylated histone H2AX (γH2AX) and open DNA ends, it has been suggested that post-meiotic DNA double-strand breaks (PM-DSBs) enable chromatin remodeling during animal spermiogenesis. However, the existence of PM-DSBs is unconfirmed, and...

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Detalles Bibliográficos
Autores principales: Akematsu, Takahiko, Fukuda, Yasuhiro, Garg, Jyoti, Fillingham, Jeffrey S, Pearlman, Ronald E, Loidl, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482572/
https://www.ncbi.nlm.nih.gov/pubmed/28621664
http://dx.doi.org/10.7554/eLife.26176