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Functional promoter upstream p53 regulatory sequence of IGFBP3 that is silenced by tumor specific methylation
BACKGROUND: Insulin-like growth factor binding protein (IGFBP)-3 functions as a carrier of insulin-like growth factors (IGFs) in circulation and a mediator of the growth suppression signal in cells. There are two reported p53 regulatory regions in the IGFBP3 gene; one upstream of the promoter and on...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548269/ https://www.ncbi.nlm.nih.gov/pubmed/15661074 http://dx.doi.org/10.1186/1471-2407-5-9 |