Functional promoter upstream p53 regulatory sequence of IGFBP3 that is silenced by tumor specific methylation

BACKGROUND: Insulin-like growth factor binding protein (IGFBP)-3 functions as a carrier of insulin-like growth factors (IGFs) in circulation and a mediator of the growth suppression signal in cells. There are two reported p53 regulatory regions in the IGFBP3 gene; one upstream of the promoter and on...

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Detalles Bibliográficos
Autores principales: Hanafusa, Tadashi, Shinji, Toshiyuki, Shiraha, Hidenori, Nouso, Kazuhiro, Iwasaki, Yoshiaki, Yumoto, Eichiro, Ono, Toshiro, Koide, Norio
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548269/
https://www.ncbi.nlm.nih.gov/pubmed/15661074
http://dx.doi.org/10.1186/1471-2407-5-9

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