Recurrent background mutations in WHI2 impair proteostasis and degradation of misfolded cytosolic proteins in Saccharomyces cerevisiae

Proteostasis promotes viability at both the cellular and organism levels by maintaining a functional proteome. This requires an intricate protein quality control (PQC) network that mediates protein folding by molecular chaperones and removes terminally misfolded proteins via the ubiquitin proteasome...

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Detalles Bibliográficos
Autores principales: Comyn, Sophie A., Flibotte, Stéphane, Mayor, Thibault
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482819/
https://www.ncbi.nlm.nih.gov/pubmed/28646136
http://dx.doi.org/10.1038/s41598-017-04525-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482819/
https://www.ncbi.nlm.nih.gov/pubmed/28646136
http://dx.doi.org/10.1038/s41598-017-04525-8

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