Inhibition of ERK1/2 Restores GSK3β Activity and Protein Synthesis Levels in a Model of Tuberous Sclerosis

Tuberous sclerosis (TS) is a multi-organ autosomal dominant disorder that is best characterized by neurodevelopmental deficits and the presence of benign tumors. TS pathology is caused by mutations in tuberous sclerosis complex (TSC) genes and is associated with insulin resistance, decreased glycoge...

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Detalles Bibliográficos
Autores principales: Pal, Rituraj, Bondar, Vitaliy V., Adamski, Carolyn J., Rodney, George G., Sardiello, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482840/
https://www.ncbi.nlm.nih.gov/pubmed/28646232
http://dx.doi.org/10.1038/s41598-017-04528-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482840/
https://www.ncbi.nlm.nih.gov/pubmed/28646232
http://dx.doi.org/10.1038/s41598-017-04528-5

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