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Loss of Gα(i) proteins impairs thymocyte development, disrupts T-cell trafficking, and leads to an expanded population of splenic CD4(+)PD-1(+)CXCR5(+/−) T-cells
Thymocyte and T cell trafficking relies on signals initiated by G-protein coupled receptors. To address the importance of the G-proteins Gα(i2) and Gα(i3) in thymocyte and T cell function, we developed several mouse models. Gα(i2) deficiency in hematopoietic progenitors led to a small thymus, a doub...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482867/ https://www.ncbi.nlm.nih.gov/pubmed/28646160 http://dx.doi.org/10.1038/s41598-017-04537-4 |