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Nucleoside reverse transcriptase inhibitors (NRTIs) induce proinflammatory cytokines in the CNS via Wnt5a signaling

HAART is very effective in suppressing HIV-1 replication in patients. However, patients staying on long-term HAART still develop various HIV-associated neurological disorders, even when the viral load is low. The underlying pathogenic mechanisms are largely unknown. Emerging evidence implicated that...

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Detalles Bibliográficos
Autores principales: Wu, Ting, Zhang, Juan, Geng, Mingxing, Tang, Shao-Jun, Zhang, Wenping, Shu, Jianhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482870/
https://www.ncbi.nlm.nih.gov/pubmed/28646196
http://dx.doi.org/10.1038/s41598-017-03446-w