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Evolution of the vertebrate insulin receptor substrate (Irs) gene family

BACKGROUND: Insulin receptor substrate (Irs) proteins are essential for insulin signaling as they allow downstream effectors to dock with, and be activated by, the insulin receptor. A family of four Irs proteins have been identified in mice, however the gene for one of these, IRS3, has been pseudoge...

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Detalles Bibliográficos
Autores principales: Al-Salam, Ahmad, Irwin, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482937/
https://www.ncbi.nlm.nih.gov/pubmed/28645244
http://dx.doi.org/10.1186/s12862-017-0994-z