Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer’s disease-like APPPS1 mice

The immunoproteasome (iP) represents a specialized type of proteasomes, which plays an important role in the clearance of oxidant-damaged proteins under inflammatory and pathological conditions determining the outcome of various diseases. In Alzheimer’s disease (AD)-like APPPS1 mice Aβ-deposition is...

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Detalles Bibliográficos
Autores principales: Wagner, Lisa K., Gilling, Kate E., Schormann, Eileen, Kloetzel, Peter M., Heppner, Frank L., Krüger, Elke, Prokop, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483273/
https://www.ncbi.nlm.nih.gov/pubmed/28646899
http://dx.doi.org/10.1186/s40478-017-0453-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483273/
https://www.ncbi.nlm.nih.gov/pubmed/28646899
http://dx.doi.org/10.1186/s40478-017-0453-5

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