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Engineered allosteric ribozymes that respond to specific divalent metal ions
In vitro selection was used to isolate five classes of allosteric hammerhead ribozymes that are triggered by binding to certain divalent metal ion effectors. Each of these ribozyme classes are similarly activated by Mn(2+), Fe(2+), Co(2+), Ni(2+), Zn(2+) and Cd(2+), but their allosteric binding site...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548338/ https://www.ncbi.nlm.nih.gov/pubmed/15681614 http://dx.doi.org/10.1093/nar/gki182 |