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Preferential binding and structural distortion by Fe(2+) at RGGG-containing DNA sequences correlates with enhanced oxidative cleavage at such sequences

Certain DNA sequences are known to be unusually sensitive to nicking via the Fe(2+)-mediated Fenton reaction. Most notable are a purine nucleotide followed by three or more G residues, RGGG, and purine nucleotides flanking a TG combination, RTGR. Our laboratory previously demonstrated that nicking i...

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Detalles Bibliográficos
Autores principales: Rai, Priyamvada, Wemmer, David E., Linn, Stuart
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548341/
https://www.ncbi.nlm.nih.gov/pubmed/15659581
http://dx.doi.org/10.1093/nar/gki192