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Preferential binding and structural distortion by Fe(2+) at RGGG-containing DNA sequences correlates with enhanced oxidative cleavage at such sequences
Certain DNA sequences are known to be unusually sensitive to nicking via the Fe(2+)-mediated Fenton reaction. Most notable are a purine nucleotide followed by three or more G residues, RGGG, and purine nucleotides flanking a TG combination, RTGR. Our laboratory previously demonstrated that nicking i...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548341/ https://www.ncbi.nlm.nih.gov/pubmed/15659581 http://dx.doi.org/10.1093/nar/gki192 |