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Repurposing a pore: highly conserved perforin-like proteins with alternative mechanisms

Pore-forming proteins play critical roles in pathogenic attack and immunological defence. The membrane attack complex/perforin (MACPF) group of homologues represents, with cholesterol-dependent cytolysins, the largest family of such proteins. In this review, we begin by describing briefly the struct...

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Detalles Bibliográficos
Autores principales: Ni, Tao, Gilbert, Robert J. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483515/
https://www.ncbi.nlm.nih.gov/pubmed/28630152
http://dx.doi.org/10.1098/rstb.2016.0212